Top Performing Leveraged/Inverse ETFs: 11/16/2025

Top Performing Leveraged/Inverse ETFs Last WeekThese were last week’s top performing leveraged and inverse ETFs. Note that because of leverage, these kinds of funds can move quickly. Always do your homework.1. SBIT – ProShares UltraShort Bitcoin ETF SBIT, which tracks -2x the daily price movements of an index that measures the price of Bitcoin, topped the list with a weekly gain of ~20%. Bitcoin’s price declined due to mounting fears of a tech bubble and decreased anticipation for a US rate cut in the coming month. 2. ETHD – ProShares UltraShort Ether ETF ETHD, which tracks -2x the daily price movements of an index that measures the price of Ethereum ETF ranked second on the ETFs’ list with ~19% weekly gains. Dampened expectations of an interest rate cut by the US Federal Reserve next month sent Bitcoin crashing to a six-month low. Ether also experienced a price fall. 3. PILL – Direxion Daily Pharmaceutical & Medical Bull 3X Shares The PILL ETF tracks the performance of companies engaged in the research, development, manufacture, sale, or distribution of pharmaceuticals and drugs of all types. The ETF was one of the top-performing levered ETFs, returning over 15% last week, driven by news of a proposed U.S. government rule change that would expand healthcare coverage for weight-loss drugs. 4. GDXU – MicroSectors Gold Miners 3X Leveraged ETN GDXU is a leveraged equity fund that provides 3x exposure to an index comprised of two of the largest gold miners’ ETFs, viz VanEck Gold Miners ETF (GDX) and VanEck Junior Gold Miners ETF (GDXJ), that invest in the global gold mining industry. GDXU returned over 14% last week. Gold prices rebounded, boosted by soft U.S. employment figures. Investors were simultaneously assessing the likelihood of a Federal Reserve interest rate cut in December, awaiting further U.S. data releases later this week. 5. LABU – Direxion Daily S&P Biotech Bull 3x Shares The biotech fund, LABU, gained over 13% and was one of the top performing levered ETFs on the list, due to strong revenue reports from companies like Nutex Health, and positive sector-wide trends like increasing demand for biotech treatments and ongoing merger and acquisition activity. 6. NRGU – MicroSectors U.S. Big Oil Index 3X Leveraged ETN NRGU, which tracks three times the performance of an index of US Oil & Gas companies, featured on the levered weekly list, returning ~12%. Oil settled higher, pulled by sanctions on Russian oil flows and President Trump’s update on the Fed Chair search. 7. CURE – Direxion Daily Healthcare Bull 3x Shares The CURE ETF offers 3x daily leveraged exposure to an index of healthcare stocks. The healthcare sector gained ~1% and was the best-performing sector in the last five days. 8. WTIU – MicroSectors Energy 3X Leveraged ETNs WTIU, an exchange-traded note that tracks 3x of the daily price movements of an index of US-listed energy and oil companies, ranked among the top-performing leveraged contenders last week. Oil prices climbed amid Western sanctions on Russian oil, as well as the President’s update on the Fed Chair search. 9. TSLQ – AXS TSLA Bear Daily ETF TSLQ provides inverse exposure to the daily price movement for shares of Tesla stock was present on the list of inverse ETFs with nearly ~11% weekly returns. Tesla’s stock price fell due to concerns over CEO Elon Musk’s approved $1 trillion pay package, declining sales in international markets like China, and a recall of its Powerwall 2 units. 10. AMDL – GraniteShares 2x Long AMD Daily ETF AMDL provides 2x leveraged exposure to the daily price movement for shares of Advanced Micro Devices stock made it to the list, with over 10% weekly gains. AMD’s stock price is up after the chipmaker unveiled a robust $100 billion annual data-center revenue target, signaling its intent to challenge Nvidia in the booming AI market. For more news, information, and analysis, visit the Leveraged & Inverse Content Hub.